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Recent Achievements
アンカー 1

1) CAPS2 Deficiency Impairs the Release of the Social Peptide Oxytocin, as Well as Oxytocin-Associated Social Behavior

We showed that CAPS2/Cadps2 deficiencies altered oxytocin release, resulting in impaired social behavior in mice.

Fujima S, Yamaga R, Minami H, Mizuno S, Shinoda Y, Sadakata T, Abe M, Sakimura K, Sano Y, and Furuichi T. CAPS2 deficiency impairs the release of the social peptide, oxytocin, as well as oxytocin-associated social behavior. Journal of Neuroscience. 41(20):4524-4535, 2021.

Impaired oxytocin-related social behavior in CAPS2/Cadps2 KO mice
アンカー 2

2) Loss of CAPS2/Cadps2 leads to exocrine pancreatic cell injury and intracellular accumulation of secretory granules in mice.

 

We showed that CAPS2/Cadps2 deficiencies in mice cause cytoplasmic accumulation of secretory granules (zymogen granules), decreased amylase secretion, and acinar cell injury in the exocrine pancreas.

 

Sato Y, Tsuyusaki M, Takahashi-Iwanaga H, Fujisawa R, Masamune A, Hamada S, Matsumoto R, Tanaka Y, Kakuta Y, Yamaguchi-Kabata Y, Furuse T, Wakana S, Shimura T, Kobayashi R, Shinoda Y, Goitsuka R, Maezawa S, Sadakata T, Sano Y, and Furuichi T. Loss of CAPS2/Cadps2 leads to exocrine pancreatic cell injury and intracellular accumulation of secretory granules in mice. Frontiers in Molecular Biosciences 9:1040237, 2022.

Pancreatic acinar cell injury in CAPS2/Cadps2 KO mice.tif
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